Yuhong Man
The Second Hospital of Jilin University, China
Title: Vitamin B12 , homocysteine level and vascular dementia
Biography
Biography: Yuhong Man
Abstract
Vitamin B12 , homocysteine level and vascular dementia: This study aim to investigate the relationship of vitamin B12, homocysteine level and vascular dementia. This was a retrospective study and we reviewed 162 patients with brain magnetic resonance imaging (MRI) and mini-mental state examination (MMSE) confirmed admitted patients with vascular dementia (VaD). Vitamin B12 and homocysteine level were assessed to determine their values for predicting functional outcome at the admission first and the follow-up 6 months clinic visits after discharge from the hospital. Associations between vitamin B12, homocysteine level and severity of VaD at admission was analyzed using logistic regression. Results have shown that serum vitamin B12 levels were significantly lower, but the plasma homocysteine level was higher in patients with VaD. High homocysteine levels were independently associated with a decreased risk of MMSE at admission score of VaD (OR 2.87, 95% CI 1.13, 4.63). We found that lower levels of vitamin B12 were associated with worse prognosis at admission and the follow-up 6 months with VaD(OR 3.40, 95% CI 1.16,8.33). Our findings suggested that higher homocysteine levels and lower levels of vitamin B12 was associated with better outcome at admission and the follow-up 6 months with VaD.